🚀 Add to Chrome – It’s Free - YouTube Summarizer
Category: Health & Wellness
Tags: Alzheimer'screatinehealthcarepreventionsupplements
Entities: Alzheimer's diseaseBobby KennedyCreatineDavid MitchellGary BreaMax Lugavere
00:00
There's now a bounty of evidence that creatine actually also supports cognitive function. I think creatine is something right now that's widely thought of as like the bodybuilding supplement.
The Alzheimer's field has been rife with fraud. There have been other papers exploring how creatine might play a therapeutic role for a
00:16
patient with Alzheimer's disease, but the first clinical trial was just published and it's incredible. I believe the pendulum is going to swing back into reasonable thought-based care that actually is sensical, just common sense.
There are many industries, many individuals that stand to gain from gatekeeping knowledge. It's corrupt that
00:33
people would want the public to be gatekept from this kind of information. You're not trying to say that there's corruption in our nutritional research, are you, Max?
I think people feel a little out of control with their healthcare choices. We are a lot more in control of our destiny than we think we are.
My whole
00:50
purpose has been to and which is I think part of why we've gathered here today for this event is to Ultimate.
01:07
Wow, dude. This is a surreal moment.
This is crazy. Can we just take this in for a second?
Um, that we're at the White House and the message is resonating. By the way, welcome back to the Ultimate Human Podcast.
I'm your host, human biologist Gary Brea. This is
01:23
Max Lug. Um he and I have had an incredible relationship that we built um over the last few years just being in the same space listening to you message and um we just both sat down here and I think it hit us both at the same time like wow we must be doing something
01:42
right to to to have gotten this incredible opportunity to be here. Um yeah and I'm just inc I'm so grateful.
I mean for me you know it's it all goes back to my why. I think you always have to remind yourself in these moments why it is that you are doing what you do.
And for me, you know, 12 years ago now
01:58
when my mom was first diagnosed with a neurodeenerative condition, I was completely in the dark, totally lost. Yeah.
And everything that has unfolded subsequently, all the knowledge that I've, you know, been humbled to have uh acrewed and all the experts that I've spoken to, it's I guess led to this
02:13
moment. Yeah.
And um yeah, it's just wonderful. Well, you know, I think that I I just did a little post about this myself.
And I know we're getting off topic, but you know, my wife and I started on our mission 10 years ago in a strip mall in Naples, Florida. We took over a little bankrupt vitamin shop and
02:30
grew it into a functional medicine business and then decided we wanted to get a message out to the masses. We started a media platform with the podcast and everything.
we started interacting with amazing people like you and the message was so unified you know and and I think it was about just getting back to the basics uh you know
02:47
huge report coming out today you and I have not seen it but we have an inkling of what's in it um I think that it is going to potentially upend modern medicine in a way that will be catastrophic and and catastrophic in a good way like just getting back to the basic principles of whole food movement
03:04
um exercise uh you know sleep, you know, supplementation for deficiency that this pandemic of chronic disease was exacerbated by chemicals, synthetics, and pharmaceuticals not solved by any of those things. And because we don't have
03:20
access to that report yet, and I don't want to steal the thunder from today's announcement, I want to talk about a couple of other things that are really in the news that I know you're familiar with. You know, I've I've I've long since been a big fan of creatine.
Um, and I think creatine is something right now that's widely thought of as like the
03:36
bodybuilding supplement and women in particular are afraid of creatine. Uh, I think for the wrong reasons because in my opinion, you know, every woman over 40 years old should be on a minimum 5 milligrams of creatine a day for cognitive function, hormone balance.
It
03:53
has so many other uh attributes in our in our body. Can you talk a little bit about the study that just just came out on creatine?
Yes. So the first ever uh clinical trial testing creatine in the setting of Alzheimer's disease was just published.
There have been other papers
04:09
um mechanistically exploring how creatine might play a therapeutic role for a patient with Alzheimer's disease but the first clinical trial was just published and it's it's incredible. Now there are some important caveats.
Um it was a small trial about 20 patients.
04:25
Mhm. It was a single arm, so there was no there was no placebo group, but as a pilot trial to test the feasibility, to test the safety, um the results were pretty impressive.
So, basically took 20 patients with Alzheimer's disease and put them on a 20 gram dose of creatine
04:41
every day. Wow.
Now, that's a big dose. So, it's about four times what they would recommend.
Some some some proponents of creatine would recommend uh creatine loading. So, like 30 days of of high dose and then backing down to five milligrams.
So this is 20 milligrams a day, right? So the the
04:57
thinking is that um over a certain period of time, you know, muscles will saturate with creatine. If you're taking 3 to five grams a day, it takes about 28 days um if you choose not to do the loading period for your muscles to fully saturate with creatine for a erogenic um
05:13
benefit or performance boosting benefit. But there's now a bounty of evidence mounting showing us that creatine actually also supports cognitive function, mental health, right?
But it's unclear at this point how much creatine
05:29
one needs to take in order for that creatine to be pushed to the brain, right? Um because at the dietary levels meet the muscle saturation needs.
So it's actually been shown that vegans and omnivores don't uh differ in terms of their brain creatine saturation. Oh wow.
05:45
So the dietary levels don't seem to modulate brain levels. Wow.
I would have thought the opposite actually. That's what I That's what I That's what I think a lot of people thought.
Yeah. I would have thought the meat eaters would have, you know, adequate levels of creatine, right?
Because meat eaters ingest it through their diets, right? And and vegans obviously don't because creatine is a carnri.
It's found exclusively in
06:02
animal source foods. Um meat and beef, red meat and fish um specifically.
But now we're starting to understand that actually it's a it takes a much higher dose um to actually push creatine to the brain. It seems to be preferentially sucked up by the muscles.
But if you
06:18
take a high enough dose, a supplementary dose, then it seems to get pushed up to the brain. And we kind of had an inkling of this when there was that study published about a year ago.
Yeah. We we talked sleep deprivation.
Yeah. when you would take like a really high dose of creatine, it seemed to have an acute
06:33
beneficial effect on cognitive function for someone who was sleepd deprived, right? But um but now thanks to this new trial that was published, we've seen that when patients again it was a short-term study uh lasted about 20
06:48
weeks um or I'm sorry eight eight weeks eight weeks uh 20 patients 8 weeks so again small 20 grams a day they saw a stat statistically significant improvement across pretty much every cognitive score. Wow.
Yeah. You know, so this is
07:05
something for the elderly. You know, I I I was actually talking to Bobby Kennedy about this um a few months ago and we were talking about supplementation modalities, treatments, care options, functional medicine alternatives that
07:21
provide a benefit but have very little chance of harm or no downside consequence. and he was saying how the lanes should be more open to things that may or may not work but actually don't
07:36
cause harm because there's a lot of pharmaceutical options that may or may not work but then there's a permanent or semi-permanent detriment. You know, you have a taplactic response, you build desensitization, you build a dependency or reliance.
Um and and those kinds of
07:52
consequences are the kinds of consequences that really need to be measured. But creatine seems to be one of those that falls into the category of there is indirect and direct anecdotal, objective, and subjective evidence that says this is beneficial for men and
08:10
women and certainly in older ages seems to be uh more beneficial because of the the depletion and the lack of absorption. And so now we have a trial that says, hey, across nearly every, excuse me, cognitive measurement, uh,
08:26
this is having an acute, you know, positive effect. Yeah.
Now, it would be amazing to have had a placebo group. It would be amazing to see if it if we see significant co cognition improvements at lower doses because 20 grams again is a high dose.
Anybody's ever had to suck
08:41
down, you know, 20 grams of creatine sand, you know, it is a sand, you know. Yeah.
Exa Exactly. Um, but you're a thousand% correct in that.
First of all, I mean, my work has been, and we talked about this on the last time I was on your show, there's been the the
08:58
Alzheimer's field has been rife with fraud. Yes.
And it really has. Yes.
And and it's also rife with taking the same objectives, the same sort of you know clinical narrative and trying to over and over and over again trying to prove
09:14
this clinical narrative of the amaloid plaques and the neuropiary tangles which we know now are consequences of not the genesis of because those are really drug centric right because they want to provide a solution to manage that
09:29
condition or to manage those symptoms not really get like what you're talking about to the root cause. What is the genesis of it?
And if we know what the genesis is, how can we reverse it? And for people that find themselves afflicted by it, is there a chance to slow, stop, or even reverse that that
09:46
and and creatine mechanistically? It's it's literally getting to the the one of the root causes of the condition, which we believe to be uh an inability of the brain to properly generate energy.
So creatine is it helps the brain it's it's
10:02
involved in in neuroenergetics the brain's ability to generate ATP which is it which is its energetic currency and in Alzheimer's disease there's a an inability a stark inability for the brain to properly generate ATP from its primary fuel substrate which is glucose.
10:18
So with creatine the thinking is you're actually getting to the root cause as opposed to these um you know these anti-amaloid drugs like lacanab and aicanamab which are just attacking this sort of downstream you know phenomena
10:34
this amaloid plaque buildup right which which do not which are which is not a free ride I mean they the risks the risks are significant brain swelling brain bleeds and even death in some of these trials Yeah, this is exactly what
10:49
Bobby was talking about is those are those kinds of consequences for the potential of doing something good uh that may or may not work but have the potential of causing permanent irreversible damage, neuroplasticity changes, other things. I think what's so
11:05
exciting now for folks like you and I is that I feel the the cover lifting for us. I feel the lanes beginning to widen for things like supplementation, peptides, um functional medicine
11:20
alternatives, lifestyle changes, interventional changes that are largely in control of the patient or the client um that wants that wants to go on this journey and not so much being practiced upon, you know, and and and that's I mean that's really exciting for for for
11:37
guys like you and I and especially given your background and the history with your mother um and your you know, you talked about this in your documentary. Um, you know, had some options like this been available, um, maybe there would have been a different course.
A thousand%. Yeah.
I mean, I would have I
11:54
would have loved to have explored creatine as a as an option, right? Um, with my mom, we obviously didn't have this this data um, back when she was alive.
And it's unfortunate the drugs that she were prescribed, I mean, were
12:09
little more than biochemical band-aids. And I don't think that they helped her at all.
In fact, I think they probably contributed to her her net decline over time. But, you know, these drugs, I mean, these creatine is it's, you know, it's not a cure.
My whole purpose has
12:24
been to and which is, I think, part of why we've gathered here today for this event is to really shift the spotlight to prevention, which I think is and awareness too, right? Because I I I think we are a lot more in control of
12:40
our destiny than we think we are. I think as humanity and you know sadly folks like you and I are somewhat in a little bit of an echo chamber because the people that are listening to us and are in our peer peer groups are becoming more and more aware and we're accepting
12:55
of this. But but my message has always been to try to get this to the masses to really push this down into humanity so that at a basic level people can get a fundamental understanding of what they can do so they can feel I think people feel a little out of control with their
13:12
healthcare choices like it's actually not their their choice they they don't have any governance over it. Yeah.
Well, there's um there are there are many industries, many individuals that stand to gain from gatekeeping knowledge, gatekeeping scientific. You're not trying to say that there's corruption in
13:28
our there's there's there's it's not just corruption. I mean, it's it's corrupt that people would want, you know, the public to be uh gatekept from this kind of information.
But we live in an incredible time. I mean, if you're not optimistic today, you're just not paying
13:44
attention. We have all of the world's knowledge at our fingertips 24 hours a day.
We have access to PubMed. Yeah.
We have access to AI. I mean, my own scientific literacy and health has improved thanks to my access to, you know, these large language models.
It's incredible. Yeah.
And so, I think we
14:00
it's such an auspicious time to be alive and to really seize the reigns of your health and and that's why I think everything everything converged to allow a day like today to happen. Yeah.
There's so many there's so many aspects of, you know, whether it's technological advancement, you know, our collective optimism, our collective desire to shake
14:18
up the status quo. Y um that's that's paved the way for a day like today.
And it's momentous. Yeah.
And definitely a parabolic rise in awareness and for folks like you and I to potentially be a small part of affecting public policy. I mean, we're talking about generational
14:34
changes. You know, our children's children, our children's grandchildren that will benefit from it.
And it's sad that the pendulum had to swing so far that it just got it went from the sublime to the ridiculous to the totally absurd. And now I believe the pendulum's going to swing back in into the middle
14:50
into reasonable thought-based care that actually is sensical. Just common sense.
Common sense. You know, it's it's astounding to me when I travel the world how people don't believe that just getting back to the simple basics of your habitual patterns during the day can
15:07
have just this dramatic effect on the long-term trajectory of your health. Man, I wish we had more time.
Yeah, brother. Dude, but sharing this moment with you, you know, you and I have been on this journey.
You're a pioneer in the industry. I I I quote you all the time on on a lot of my podcasts and um I I
15:24
wish you the best in your journey. Likewise.
Thank you, brother. Yeah, thanks for being a Yeah.
Proud to be a foot soldier on the ground with you and um and and everybody involved. You know, this is not a There's one of my favorite lines from David David Mitchell, who is the author of Cloud Atlas.
I am but one drop in an endless ocean, yet what is
15:41
any o ocean but a multitude of drops. And wow.
Yeah. And so, uh I'm just proud to be here and to have a voice and um yeah, good things ahead.
Proud to be on the stage with you, too, brother. All right.
Good luck. Thanks.
Till next time, guys. That's just science.